Classification Of Suspension

Classification of suspension

Pharmaceutical suspension:

Pharmaceutical suspension is biphasic, heterogeneous system in which solid particles are suspended uniformly throughout the solvent is called suspension.

Solid particles:

Suspended solid / internal phase / discontinuous phase / API (therapeutic agent) / dispersed phase


Suspended medium / dispersion medium / external phase / continuous phase

They are insoluble in solvent that is why suspended in nature.

Reason for suspension dosage form:

  1. Insoluble solid particles (API)
  2. To mask the bitter taste of drug
  3. To enhance the rate of absorption of drug (applied to all dosage form)
  4. To control / sustained the release of drug
  5. More stable dosage form

Properties of suspension:

  1. It should be easily redispersed
  2. No formation of hard cake
  3. It should be physically and chemically stable
  4. Free from gretty properties

Classification of suspension:

1-based on route of administration

A) Oral suspension

B) Topical suspension

C) Parenteral suspension

A) Oral suspension:

For example

  • Tetracycline
  • Paracetamol
  • Antacid

B) Topical suspension:

For example

  • Calcium lotion

C)parenteral suspension:

For example

  • Procain
  • Pencillin G suspension
  • Insulin zinc suspension

2-Based on concentration of solid particles:

A) 2-10% W/V suspension

B) 50% W/V suspension

A) 2-10% W/V suspension:

Diluent suspension

For example

  • Steroids
  • Prednesolone acetate
  • Cortisone acetate

B)50% W/V suspension:

Concentrated suspension

For example

  • zinc oxide suspension

3-based on size of solid particles:

A) Colloidal suspension

B) Coarse suspension

A) Colloidal suspension:

In colloidal suspension particle size should be less than 1 micron meter.

B) Coarse suspension:

In coarse suspension particles size should be more than 1 micron meter.

4-based on behaviour of dispersed phase

A) Flocculated suspension

B) Deflocculated suspension

Difference between flocculated and deflocculated suspension:

Flocculated suspension:

  • In flocculated suspension there is the formation of flocks of dispersed phase in dispersion medium.

What is flocks?

Flocks is lose aggregates or network of particles and they are porous in nature.

  • Flocculated suspension are pharmaceutically more stable form they are easily re dispersed.
  • In flocculated suspension rate of sedimentation is fast.
  • In flocculated suspension sediment is rapidly form and loosely packed that’s why no formation of hard cake.
  • The flocculated suspension use for long term.
  • Flock stick to the side of container.

When flocks settle down we get cleared supernated liquid.

  • In flocculated suspension We add flocculating agent.

Deflocculated suspension:

In deflocculated the individual particle dispersed in dispersion medium.

  • In deflocculated suspension rate of sedimentation is slow.
  • In deflocculated suspension sediment is closely packed and form a hard cake.
  • Deflocculated suspension is good for short period of time not useful for long period.
  • In deflocculated suspension individual particles do not stick to the walls of container.
  • Large size particles settle down and small size particles remain dispersed so there will be no supernated liquid.
  • In deflocculated suspension we add deflocculating agent.

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Classification of suspension

Classification based on route of administration

Examples of oral suspension

Examples of topical suspension

Examples of parenteral suspension

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What is 50% W/V suspension?

Classification based on size of solid particles

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Classification based on behaviour of dispersed phase

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What is deflocculated suspension?

Differences between flocculated suspension and deflocculated suspension

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